Kim Clijsters defeated Venus Williams in the final, 6–2, 6–1 to win the women's singles tennis title at the 2010 Miami Open. It was her second Miami Open title. Victoria Azarenka was the defending champion, but lost to Clijsters in the fourth round.

Seeds

All seeds receive a bye into the second round. • # 🇷🇺 Svetlana Kuznetsova (fourth round) • # Caroline Wozniacki (quarterfinals) • # 🇺🇸 Venus Williams (final) • # 🇧🇾 Victoria Azarenka (fourth round) • # 🇷🇺 Elena Dementieva (second round) • # 🇵🇱 Agnieszka Radwańska (quarterfinals) • # 🇷🇸 Jelena Janković (fourth round) • # 🇨🇳 Li Na (second round) • # 🇦🇺 Samantha Stosur (quarterfinals) • # 🇮🇹 Flavia Pennetta (second round) • # 🇷🇺 Vera Zvonareva (fourth round) • # 🇧🇪 Yanina Wickmayer (quarterfinals) • # 🇫🇷 Marion Bartoli (semifinals) • # 🇧🇪 Kim Clijsters (champion) • # 🇮🇹 Francesca Schiavone (third round) • # 🇷🇺 Nadia Petrova (third round) • # 🇮🇱 Shahar Pe'er (third round) • # 🇫🇷 Aravane Rezaï (second round) • # 🇸🇰 Daniela Hantuchová (fourth round) • # 🇨🇳 Zheng Jie (second round) • # 🇺🇦 Alona Bondarenko (second round) • # 🇷🇺 Anastasia Pavlyuchenkova (fourth round) • # 🇩🇪 Sabine Lisicki (second round, retired due to a left ankle injury) • # 🇷🇺 Alisa Kleybanova (second round) • # 🇷🇸 Ana Ivanovic (third round) • # 🇸🇰 Dominika Cibulková (third round) • # 🇭🇺 Ágnes Szávay (third round) • # 🇷🇺 Elena Vesnina (third round) • # 🇪🇸 María José Martínez Sánchez (second round) • # 🇪🇸 Anabel Medina Garrigues (second round) • # 🇨🇦 Aleksandra Wozniak (second round) • # 🇷🇺 Maria Kirilenko (third round)

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8