The 2010 Samarkand Challenger was a professional tennis tournament played on outdoor red clay courts. It was the fourteenth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Samarkand, Uzbekistan between 9 and 14 August 2010.

ATP entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received a Special Exempt into the main draw: The following players received entry from the qualifying draw:

Champions

Singles

🇸🇰 Andrej Martin def. 🇸🇰 Marek Semjan, 6–4, 7–5

Doubles

Andis Juška / Deniss Pavlovs def. Lee Hsin-han / Yang Tsung-hua, 7–5, 6–3