The 2010 Open de Nice Côte d'Azur was a men's tennis tournament play on outdoor clay courts. It was the 26th edition of the Open de Nice Côte d'Azur, and was part of the 250 series of the 2010 ATP World Tour. It took place at the Nice Lawn Tennis Club in Nice, France, from 17 May through 22 May 2010. Unseeded Richard Gasquet won the singles title.

Finals

Singles

🇫🇷 Richard Gasquet defeated 🇪🇸 Fernando Verdasco, 6–3, 5–7, 7–6(7–5)

Doubles

🇧🇷 Marcelo Melo / 🇧🇷 Bruno Soares defeated 🇮🇳 Rohan Bopanna / 🇵🇰 Aisam-ul-Haq Qureshi, 1–6, 6–3, [10–5]

Entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received the lucky loser spot: