Rafael Nadal defeated the defending champion Roger Federer in a rematch of the previous year's final, 6–4, 7–6(7–5) to win the men's singles tennis title at the 2010 Madrid Open.

Seeds

The top eight seeds receive a bye into the second round. • # Roger Federer (final) • # 🇪🇸 Rafael Nadal (champion) • # 🇬🇧 Andy Murray (quarterfinals) • # 🇸🇪 Robin Söderling (second round) • # 🇺🇸 Andy Roddick (withdrew due to stomach virus) • # 🇪🇸 Fernando Verdasco (third round) • # 🇫🇷 Jo-Wilfried Tsonga (second round, retired due to back injury) • # Marin Čilić (third round) • # 🇪🇸 David Ferrer (semifinals) • # 🇷🇺 Mikhail Youzhny (second round) • # 🇨🇿 Tomáš Berdych (withdrew due to right hip injury) • # 🇫🇷 Gaël Monfils (quarterfinals) • # 🇺🇸 John Isner (third round) • # 🇺🇸 Sam Querrey (first round) • # Stanislas Wawrinka (third round) • # 🇧🇷 Thomaz Bellucci (second round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

Qualifying

Seeds

• # 🇦🇷 Juan Ignacio Chela (qualified) • # 🇦🇷 Eduardo Schwank (withdrew) • # 🇨🇴 Santiago Giraldo (qualified) • # 🇺🇦 Alexandr Dolgopolov (qualified) • # 🇨🇴 Alejandro Falla (first round) • # 🇺🇸 Michael Russell (qualifying competition, retired due to wrist injury, lucky loser) • # Kevin Anderson (qualified) • # 🇺🇸 Mardy Fish (qualifying competition, lucky loser) • # 🇪🇸 Daniel Gimeno Traver (qualified) • # 🇪🇸 Óscar Hernández (qualifying competition, lucky loser) • # 🇪🇸 Iván Navarro (qualifying competition) • # 🇮🇹 Filippo Volandri (qualifying competition) • # Ilija Bozoljac (first round) • # 🇧🇷 João Souza (first round)

Qualifiers

• # 🇦🇷 Juan Ignacio Chela • # 🇪🇸 Daniel Muñoz de la Nava • # 🇨🇴 Santiago Giraldo • # 🇺🇦 Alexandr Dolgopolov • # 🇧🇪 Christophe Rochus • # 🇪🇸 Daniel Gimeno Traver • # Kevin Anderson

Lucky losers

• # 🇺🇸 Michael Russell • # 🇺🇸 Mardy Fish • # 🇪🇸 Óscar Hernández

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

Seventh qualifier