The 2010 Madrid Masters (also known as the Mutua Madrileña Madrid Open for sponsorship reasons) was played on outdoor clay courts at the Park Manzanares in Madrid, Spain from May 7–16. It was the 9th edition of the event on the ATP and 2nd on the WTA. It was classified as an ATP World Tour Masters 1000 event on the 2010 ATP World Tour and a Premier Mandatory event on the 2010 WTA Tour.

ATP entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following players received lucky loser spots:

Withdrawals

The following notable players withdrew from the event:

WTA entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received the lucky loser spot:

Withdrawals

The following notable players withdrew from this event:

Finals

Men's singles

🇪🇸 Rafael Nadal defeated Roger Federer 6–4, 7–6(7–5)

Women's singles

🇫🇷 Aravane Rezaï defeated 🇺🇸 Venus Williams 6–2, 7–5

Men's doubles

🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan defeated 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić 6–3, 6–4

Women's doubles

🇺🇸 Serena Williams / 🇺🇸 Venus Williams defeated 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta 6–2, 7–5