The 2010 Medibank International Sydney was a tennis tournament played on outdoor hard courts. It was the 118th edition of the event known that year as the Medibank International Sydney, and was part of the ATP World Tour 250 series of the 2010 ATP World Tour, and of the WTA Premier tournaments of the 2010 WTA Tour. Both the men's and the women's events took place at the NSW Tennis Centre in Sydney, Australia, from 10 through 16 January 2010. Coverage of the event was on Channel Seven, with live coverage of the day sessions and delayed coverage of the night sessions.

WTA entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw through qualifying: The following players received entry into the singles main draw through the virtue of being a lucky loser:

ATP entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw through qualifying: The following players received the lucky loser spot:

Finals

Men's singles

🇨🇾 Marcos Baghdatis defeated 🇫🇷 Richard Gasquet, 6–4, 7–6(7–2)

Women's singles

🇷🇺 Elena Dementieva defeated 🇺🇸 Serena Williams, 6–3, 6–2

Men's doubles

🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić defeated 🇬🇧 Ross Hutchins / 🇦🇺 Jordan Kerr, 6–3, 7–6(7–5).

Women's doubles

Cara Black / 🇺🇸 Liezel Huber defeated 🇮🇹 Tathiana Garbin / 🇷🇺 Nadia Petrova, 6–1, 3–6, [10–3]