The 2010 Italian Open (also known as the 2010 Rome Masters and sponsored title 2010 Internazionali BNL d'Italia) was a tennis tournament, being played on outdoor clay courts at the Foro Italico in Rome, Italy. It was the 67th edition of the event and was classified as an ATP World Tour Masters 1000 event on the 2010 ATP World Tour and a Premier 5 event on the 2010 WTA Tour. The men's event took place from April 24 to May 2, 2010 while the women's event took place from April 30 to May 8, 2010.

Finals

Men's singles

🇪🇸 Rafael Nadal defeated 🇪🇸 David Ferrer, 7–5, 6–2

Women's singles

🇪🇸 María José Martínez Sánchez defeated 🇷🇸 Jelena Janković, 7–6(5), 7–5

Men's doubles

🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan defeated 🇺🇸 John Isner / 🇺🇸 Sam Querrey, 6–2, 6–3

Women's doubles

🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta defeated 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez, 6–4, 6–2

ATP entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following player received special exempt into the main draw: The following players received entry via qualifying: The following player received the lucky loser spot:

Withdrawals

The following notable players withdrew from the event:

WTA entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry via qualifying: The following player received the lucky loser spot:

Withdrawals

The following notable player withdrew from the event: