The 2010 InterLiga was the seventh and last edition of the tournament. It determined the last two Mexican berths in the 2010 Copa Libertadores.

Venues

Qualification

Qualification to this year's InterLiga remains the same. The qualified teams were the eight best-positioned teams in the 2009 Apertura general table who did not qualify for the 2010 Copa Libertadores directly (Morelia, San Luis, and Guadalajara) and did not qualify for the 2009–10 CONCACAF Champions League from the previous season (Toluca, Cruz Azul, Pachuca, and UNAM).

Group stage

Group A

Group B

Finals

Kickoffs are given in UTC-6.

Goalscorers