Rafael Nadal defeated Robin Söderling in the final, 6–4, 6–2, 6–4 to win the men's singles tennis title at the 2010 French Open. It was his fifth French Open title and his seventh major title overall. Nadal won the title without dropping a set for the second time (the first being in 2008). By winning the title, Nadal regained the world No. 1 ranking from Roger Federer, who was in contention to break Pete Sampras' record of 286 weeks spent with the top position. Federer was the defending champion, but lost in the quarterfinals to Söderling in a rematch of the previous year's final. This was the first time since the 2004 French Open that Federer did not reach the semifinals of a major, a span of 23 majors. Federer was attempting to become the first man in the Open Era and the third man ever to achieve a double career Grand Slam. Between the 2004 Wimbledon Championships and the 2017 Australian Open, this was the only major not to feature either Federer or Novak Djokovic in the semifinals. Djokovic's quarterfinal match against Jürgen Melzer marked the only time he lost a match at a major after leading two sets to love.

Seeds

• Roger Federer (quarterfinals) • 🇪🇸 Rafael Nadal (champion) • 🇷🇸 Novak Djokovic (quarterfinals) • 🇬🇧 Andy Murray (fourth round) • 🇸🇪 Robin Söderling (final) • 🇺🇸 Andy Roddick (third round) • 🇪🇸 Fernando Verdasco (fourth round) • 🇫🇷 Jo-Wilfried Tsonga (fourth round, retired because of a right leg injury) • 🇪🇸 David Ferrer (third round) • Marin Čilić (fourth round) • 🇷🇺 Mikhail Youzhny (quarterfinals) • Fernando González (second round) • 🇫🇷 Gaël Monfils (second round) • Ivan Ljubičić (third round) • 🇨🇿 Tomáš Berdych (semifinals) • 🇪🇸 Juan Carlos Ferrero (third round) • 🇺🇸 John Isner (third round) • 🇺🇸 Sam Querrey (first round) • 🇪🇸 Nicolás Almagro (quarterfinals) • Stan Wawrinka (fourth round) • 🇪🇸 Tommy Robredo (first round) • 🇦🇹 Jürgen Melzer (semifinals) • Ernests Gulbis (first round) • 🇧🇷 Thomaz Bellucci (fourth round) • 🇨🇾 Marcos Baghdatis (third round) • 🇦🇷 Juan Mónaco (first round) • 🇪🇸 Feliciano López (first round) • 🇦🇺 Lleyton Hewitt (third round) • 🇪🇸 Albert Montañés (third round) • 🇩🇪 Philipp Kohlschreiber (third round) • 🇷🇴 Victor Hănescu (third round) • 🇪🇸 Guillermo García López (second round)

Qualifying

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8