The 2010 Fifth Third Bank Tennis Championships was a professional men's tennis tournament played on hard court. It was a sixteenth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Lexington, Kentucky, United States, between 19 July and 24 July 2010.

Singles main-draw entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw:

Champions

Singles

🇦🇺 Carsten Ball defeated 🇺🇸 Jesse Levine, 6–4, 7–6(7–1)

Doubles

Raven Klaasen / Izak van der Merwe defeated 🇦🇺 Kaden Hensel / 🇦🇺 Adam Hubble, 5–7, 6–4, [10–7]