The 2010 Fergana Challenger was a professional tennis tournament played on outdoor hard courts. It was part of the 2010 ATP Challenger Tour. It took place in Fergana, Uzbekistan between May 17 and May 22, 2010.

ATP entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received special exempt into the main draw: The following player received entry with a protected ranking:

Champions

Singles

🇷🇺 Evgeny Kirillov def. 🇨🇳 Zhang Ze, 6–3, 2–6, 6–2

Doubles

🇺🇸 Brendan Evans / 🇯🇵 Toshihide Matsui def. 🇨🇳 Gong Maoxin / 🇨🇳 Li Zhe, 3–6, 6–3, [10–8]