The 2010 Estoril Open was a tennis tournament played on outdoor clay courts. It was the 21st edition of the Estoril Open for the men (the 14th for the women), and was part of the ATP World Tour 250 series of the 2010 ATP World Tour, and of the International-level tournaments of the 2010 WTA Tour. Both the men's and the women's events took place at the Estádio Nacional in Oeiras, Portugal, from 3 May until 9 May 2010. Albert Montañés and Anastasija Sevastova won the singles title.

ATP entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following players received the lucky loser spot:

Withdrawals

The following notable players withdrew from the event:

WTA entrants

Seeds

Other entrants

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received the lucky loser spot:

Finals

Men's singles

🇪🇸 Albert Montañés defeated Frederico Gil, 6–2, 6–7(4–7), 7–5

Women's singles

Anastasija Sevastova defeated 🇪🇸 Arantxa Parra Santonja, 6–2, 7–5

Men's doubles

🇪🇸 Marc López / 🇪🇸 David Marrero defeated Pablo Cuevas / 🇪🇸 Marcel Granollers, 6–7(1–7), 6–4, [10–4]

Women's doubles

🇷🇴 Sorana Cîrstea / 🇪🇸 Anabel Medina Garrigues defeated 🇷🇺 Vitalia Diatchenko / 🇫🇷 Aurélie Védy, 6–1, 7–5