The 2010 Comerica Bank Challenger was a professional tennis tournament played on hard court. This was the twenty-third edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Aptos, United States between 12 July and 18 July 2010.

Singles main draw entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received a place as a special entrant: The following players received entry from the qualifying draw:

Champions

Singles

🇦🇺 Marinko Matosevic def. 🇺🇸 Donald Young, 6–4, 6–2

Doubles

🇦🇺 Carsten Ball / 🇦🇺 Chris Guccione def. 🇦🇺 Adam Feeney / 🇦🇺 Greg Jones, 6–1, 6–3