The 2010 CFU Club Championship was the 12th edition of the CFU Club Championship, the annual international club football competition in the Caribbean region, held amongst clubs whose football associations are affiliated with the Caribbean Football Union (CFU). The top three teams in the tournament qualified for the 2010–11 CONCACAF Champions League.

Qualified clubs

The following clubs were all entered into the competition.

Competition format

The competition was initially announced by the CFU to be structures similarly to the previous year, during which several team played two-legged playoffs and other seed teams received byes in the later knockout rounds. However, the format was changed at the 2010 CFU Congress, where it was decided that three rounds of group stages would be used. Also, Haiti, who had not initially entered any clubs into the tournament, added Racing Gonaïves and Tempête. Elite SC from Cayman Islands were also later added. However, Elite SC and Bath Estate later withdrew from the tournament, and Guyana Defence Force were moved to Group D due to travel and immigration difficulties. Those changes reduced Group B to two teams, both of which qualify to the second round.

First round

The top two teams from each group as well as the highest ranked third place team advance to the second round.

Group A

All matches hosted in Netherlands Antilles.

Group B

All matches hosted in Puerto Rico. Officially, Bayamón FC played as visitor in the first leg.

Group C

All matches hosted in Saint Vincent and the Grenadines.

Group D

All matches hosted in Guyana.

Second round

In the second round, only the group winners advance to the final round. After the completion of the first round, the following changes to the second round have been made:

Group E

All matches hosted in Puerto Rico.

Group F

All matches hosted in Puerto Rico.

Group G

All matches hosted in Trinidad & Tobago.

Group H

All matches hosted in Trinidad & Tobago.

Final round

The top three finishers qualify for the preliminary round of the 2010–11 CONCACAF Champions League. All matches hosted in Trinidad & Tobago.

Top goalscorers

Updated for all matches.