Jelena Janković defeated Caroline Wozniacki in the final, 6–2, 6–4 to win the women's singles tennis title at the 2010 Indian Wells Masters. Vera Zvonareva was the defending champion, but lost in the fourth round to Samantha Stosur. This tournament marked the first WTA Tour main draw appearance of future World No. 3 and US Open Champion Sloane Stephens, who advanced to the second round before losing to Zvonareva.

Seeds

All seeds receive a bye into the second round. • # 🇷🇺 Svetlana Kuznetsova (second round) • # Caroline Wozniacki (final) • # 🇧🇾 Victoria Azarenka (third round) • # 🇷🇺 Elena Dementieva (quarterfinals) • # 🇵🇱 Agnieszka Radwańska (semifinals) • # 🇷🇸 Jelena Janković (champion) • # 🇨🇳 Li Na (second round) • # 🇦🇺 Samantha Stosur (semifinals) • # 🇮🇹 Flavia Pennetta (third round) • # 🇷🇺 Maria Sharapova (third round) • # 🇫🇷 Marion Bartoli (fourth round) • # 🇷🇺 Vera Zvonareva (fourth round) • # 🇧🇪 Yanina Wickmayer (fourth round) • # 🇧🇪 Kim Clijsters (third round) • # 🇮🇹 Francesca Schiavone (third round) • # 🇷🇺 Nadia Petrova (fourth round) • # 🇮🇱 Shahar Pe'er (fourth round) • # 🇨🇳 Zheng Jie (quarterfinals) • # 🇫🇷 Aravane Rezaï (fourth round) • # 🇺🇦 Alona Bondarenko (second round) • # 🇸🇰 Daniela Hantuchová (second round) • # 🇩🇪 Sabine Lisicki (second round, retired due to a left ankle injury) • # 🇷🇺 Alisa Kleybanova (quarterfinals) • # 🇷🇸 Ana Ivanovic (second round) • # 🇷🇺 Anastasia Pavlyuchenkova (third round) • # 🇸🇰 Dominika Cibulková (second round) • # 🇭🇺 Ágnes Szávay (third round) • # 🇪🇸 María José Martínez Sánchez (quarterfinals) • # 🇪🇸 Anabel Medina Garrigues (second round) • # 🇨🇦 Aleksandra Wozniak (second round) • # 🇦🇷 Gisela Dulko (third round) • # 🇷🇺 Maria Kirilenko (third round)

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8