Defending champions Serena and Venus Williams defeated Cara Black and Liezel Huber in the final, 6–4, 6–3 to win the women's doubles tennis title at the 2010 Australian Open. It was the Williams sisters' fourth Australian Open doubles title together, and eleventh major title together overall. It was also the third component of an eventual non-calendar-year Grand Slam.

Seeds

• # Cara Black / 🇺🇸 Liezel Huber (final) • # 🇺🇸 Serena Williams / 🇺🇸 Venus Williams (champions) • # 🇪🇸 Nuria Llagostera Vives / 🇪🇸 María José Martínez Sánchez (third round) • # Hsieh Su-wei / 🇨🇳 Peng Shuai (third round) • # 🇷🇺 Nadia Petrova / 🇦🇺 Samantha Stosur (first round) • # 🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs (semifinals) • # 🇷🇺 Alisa Kleybanova / 🇮🇹 Francesca Schiavone (quarterfinals) • # 🇺🇸 Bethanie Mattek-Sands / 🇨🇳 Yan Zi (quarterfinals) • # 🇷🇺 Elena Vesnina / 🇨🇳 Zheng Jie (third round) • # 🇮🇳 Sania Mirza / 🇪🇸 Virginia Ruano Pascual (third round) • # 🇷🇺 Alla Kudryavtseva / 🇷🇺 Ekaterina Makarova (second round) • # Chuang Chia-jung / 🇨🇿 Květa Peschke (second round) • # 🇦🇷 Gisela Dulko / 🇮🇹 Flavia Pennetta (quarterfinals) • # 🇩🇪 Anna-Lena Grönefeld / 🇺🇸 Vania King (second round) • # 🇷🇺 Maria Kirilenko / 🇵🇱 Agnieszka Radwańska (semifinals) • # 🇨🇿 Iveta Benešová / 🇨🇿 Barbora Záhlavová-Strýcová (second round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4