This article details the 2010–11 UEFA Europa League qualifying phase and play-off round. Each tie was played over two legs, with each team playing one leg at home. The team that had the higher aggregate score over the two legs progressed to the next round. In the event that aggregate scores finished level, the away goals rule was applied; i.e., the team that scored more goals away from home over the two legs progressed. If away goals were also equal, then 30 minutes of extra time was played, divided into two 15-minute halves. The away goals rule was again applied after extra time; i.e., if there were goals scored during extra time and the aggregate score was still level, the visiting team qualified by virtue of more away goals scored. If no goals were scored during extra time, the tie was decided by a penalty shootout. All times are CEST (UTC+2)

Round and draw dates

All draws were held at UEFA headquarters in Nyon, Switzerland. Matches may also be played on Tuesdays or Wednesdays instead of the regular Thursdays due to scheduling conflicts.

Teams

Below are the 160 teams involved in the qualifying phase and play-off round, grouped by their starting rounds. The 37 winners of the play-off round qualified for the group stage to join the 10 losing teams from the Champions League play-off round, and the title holders, Atlético Madrid. In each round, teams were seeded based on their 2010 UEFA club coefficients. Prior to the draw, UEFA may form "groups" in accordance with the principles set by the Club Competitions Committee, but they are purely for convenience of the draw and do not resemble any real groupings in the sense of the competition, while ensuring that teams from the same association not drawn against each other. CL-c Losing teams from the Champions League third qualifying round (Champions Path) CL-n Losing teams from the Champions League third qualifying round (Non-Champions Path)

First qualifying round

Seeding

Matches

<section begin=Q1 /> The first legs were played on 1 July, and the second legs were played on 8 July 2010.

First leg

Second leg

Anorthosis won 4–0 on aggregate. Tauras Tauragė won 5–4 on aggregate. Qarabağ won 5–2 on aggregate. Mogren won 5–0 on aggregate. Šibenik won 3–0 on aggregate. Dinamo Tbilisi won 2–1 on aggregate. ''1–1 on aggregate. Olimpia won on away goals.'' Bnei Yehuda won 1–0 on aggregate. Portadown won 2–1 on aggregate. MYPA won 7–0 on aggregate. Dnepr Mogilev won 8–2 on aggregate. Randers won 7–3 on aggregate. ''1–1 on aggregate. Dacia won on away goals.'' Győri ETO won 5–3 on aggregate. KF Tirana won 1–0 on aggregate. Gefle won 4–1 on aggregate. Rabotnički won 11–0 on aggregate. TPS won 7–1 on aggregate. Zrinjski won 4–2 on aggregate. Dundalk won 5–4 on aggregate. Kalmar FF won 4–0 on aggregate. Široki Brijeg won 5–0 on aggregate. Zestaponi won 5–0 on aggregate. KR Reykjavík won 5–2 on aggregate. Ruch Chorzów won 3–1 on aggregate. Torpedo Zhodino won 6–1 on aggregate.

Second qualifying round

Seeding

Matches

<section begin=Q2 /> The first legs were played on 15 July, and the second legs were played on 22 and 23 July 2010.

First leg

Second leg

Rabotnički won 1–0 on aggregate. Teteks won 3–1 on aggregate. OFK Beograd won 3–2 on aggregate. Zestaponi won 3–1 on aggregate. Maccabi Tel Aviv won 3–2 on aggregate. Spartak Zlatibor Voda won 5–3 on aggregate. Qarabağ won 3–2 on aggregate. ''2–2 on aggregate. Cercle Brugge won on away goals.'' ''3–3 on aggregate. Dnepr Mogilev won on away goals.'' Austria Wien won 3–2 on aggregate. ''2–2 on aggregate. Molde won on away goals.'' Baník Ostrava won 6–0 on aggregate. Dinamo Minsk won 10–1 on aggregate. Karpaty Lviv won 6–2 on aggregate. Kalmar FF won 2–0 on aggregate. Replay: MYPA won 8–0 on aggregate. Dinamo Tbilisi won 4–2 on aggregate. Randers won 4–1 on aggregate. Elfsborg won 3–1 on aggregate. APOEL won 6–1 on aggregate. Utrecht won 5–1 on aggregate. Shamrock Rovers won 2–1 on aggregate. Dinamo București won 7–1 on aggregate. Anorthosis won 3–2 on aggregate. Wisła won 7–0 on aggregate. Brøndby won 3–0 on aggregate. Levski Sofia won 8–0 on aggregate. Beşiktaş won 7–0 on aggregate. ''1–1 on aggregate. Ruch won on away goals.'' Rapid Wien won 6–2 on aggregate. Maribor won 3–1 on aggregate. Bangor City won 3–2 on aggregate. Győri ETO won 5–0 on aggregate. Zrinjski won 13–3 on aggregate. Olympiacos won 11–1 on aggregate. Lausanne-Sport won 2–1 on aggregate. Marítimo won 6–4 on aggregate. Cliftonville won 1–0 on aggregate. Budućnost Podgorica won 4–2 on aggregate. Motherwell won 2–0 on aggregate.

Third qualifying round

Seeding

Matches

<section begin=Q3 /> The first legs were played on 27 and 29 July, and the second legs were played on 3 and 5 August 2010.

First leg

Second leg

Rapid Wien won 4–1 on aggregate. Elfsborg won 7–1 on aggregate. Galatasaray won 7–3 on aggregate. Dnepr Mogilev won 3–1 on aggregate. Karpaty Lviv won 2–0 on aggregate. Qarabağ won 4–2 on aggregate. Dinamo Minsk won 3–2 on aggregate. Sturm Graz won 3–1 on aggregate. Anorthosis won 3–2 on aggregate. ''2–2 on aggregate. Sibir Novosibirsk won on away goals.'' AZ won 2–1 on aggregate. Dnipro Dnipropetrovsk won 3–2 on aggregate. Timișoara won 5–4 on aggregate. Brøndby won 3–1 on aggregate. Lausanne-Sport won 4–3 on aggregate. Utrecht won 4–1 on aggregate. Levski Sofia won 6–3 on aggregate. Aris won 4–3 on aggregate. Genk won 8–3 on aggregate. Beşiktaş won 4–1 on aggregate. ''2–2 on aggregate. Maccabi Tel Aviv won on away goals.'' APOEL won 4–1 on aggregate. Marítimo won 10–3 on aggregate. Slovan Bratislava won 3–2 on aggregate. Austria Wien won 6–1 on aggregate. VfB Stuttgart won 5–4 on aggregate. Hajduk Split won 4–3 on aggregate. Liverpool won 4–0 on aggregate. CSKA Sofia won 5–1 on aggregate. Juventus won 3–0 on aggregate. Maribor won 6–2 on aggregate. ''1–1 on aggregate. Győri ETO won 4–3 on penalties.'' Motherwell won 4–1 on aggregate. Odense won 5–3 on aggregate. Sporting won 3–1 on aggregate.