Rafael Nadal defeated Novak Djokovic in the final, 7–6(8–6), 7–5 to win the singles tennis title at the 2008 Queen's Club Championships. Andy Roddick was the defending champion, but lost in the semifinals to Nadal. This marked the first time since 1999 that neither Lleyton Hewitt nor Roddick won the title.

Seeds

The top eight seeds receive a bye into the second round. • # 🇪🇸 Rafael Nadal (champion) • # 🇷🇸 Novak Djokovic (final) • # 🇺🇸 Andy Roddick (semifinals) • # 🇦🇷 David Nalbandian (semifinals) • # 🇫🇷 Richard Gasquet (quarterfinals) • # 🇬🇧 Andy Murray (quarterfinals, withdrew due to a thumb injury) • # 🇫🇷 Paul-Henri Mathieu (third round) • # Ivo Karlović (quarterfinals) • # 🇪🇸 Fernando Verdasco (second round) • # Fernando González (third round) • # 🇦🇺 Lleyton Hewitt (quarterfinals) • # 🇮🇹 Andreas Seppi (second round) • # 🇷🇸 Janko Tipsarević (third round) • # 🇪🇸 Feliciano López (first round) • # 🇺🇸 Mardy Fish (third round, retired due to an ankle injury) • # 🇺🇸 Sam Querrey (first round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4