Defending champion Jelena Janković defeated Alizé Cornet in the final, 6–2, 6–2 to win the women's singles tennis title at the 2008 Italian Open. Cornet entered the tournament as a qualifier.

Seeds

The top eight seeds receive a bye into the second round. • # 🇷🇸 Ana Ivanovic (second round) • # 🇷🇺 Maria Sharapova (semifinals, withdrew due to a left calf strain) • # 🇷🇺 Svetlana Kuznetsova (third round) • # 🇷🇸 Jelena Janković (champion) • # 🇺🇸 Serena Williams (quarterfinals, withdrew due to a back injury) • # 🇷🇺 Anna Chakvetadze (semifinals) • # 🇺🇸 Venus Williams (quarterfinals) • # 🇫🇷 Marion Bartoli (third round) • # Patty Schnyder (quarterfinals) • # 🇷🇺 Vera Zvonareva (third round) • # 🇭🇺 Ágnes Szávay (second round) • # 🇵🇱 Agnieszka Radwańska (third round) • # 🇨🇿 Nicole Vaidišová (first round) • # 🇷🇺 Dinara Safina (withdrew due to a low back injury) • # 🇮🇱 Shahar Pe'er (withdrew due to a right shoulder tendinitis) • # 🇫🇷 Amélie Mauresmo (withdrew due to right intercostal muscle strain) • # 🇮🇹 Francesca Schiavone (second round) • # 🇷🇺 Nadia Petrova (first round) • # 🇦🇹 Sybille Bammer (first round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

Qualifying

Seeds

• # 🇫🇷 Alizé Cornet (qualified) • # 🇷🇺 Elena Vesnina (qualified) • # 🇫🇷 Pauline Parmentier (first round) • # 🇨🇿 Klára Zakopalová (qualified) • # 🇦🇺 Casey Dellacqua (first round) • # 🇪🇪 Kaia Kanepi (qualified) • # 🇺🇦 Mariya Koryttseva (qualified) • # 🇷🇺 Alisa Kleybanova (qualified) • # 🇺🇿 Akgul Amanmuradova (qualified) • # 🇺🇸 Jill Craybas (qualified) • # 🇨🇳 Peng Shuai (qualified) • # 🇧🇬 Tsvetana Pironkova (qualified) • # 🇷🇺 Anastasia Rodionova (qualifying competition, lucky loser) • # Timea Bacsinszky (first round) • # 🇪🇸 Virginia Ruano Pascual (qualifying competition, lucky loser) • # 🇷🇺 Ekaterina Makarova (qualifying competition, lucky loser) • # 🇵🇱 Marta Domachowska (first round) • # 🇺🇦 Olga Savchuk (qualifying competition, lucky loser) • # 🇨🇿 Iveta Benešová (qualified) • # 🇪🇸 Nuria Llagostera Vives (Still competing in Berlin) • # 🇷🇺 Galina Voskoboeva (qualifying competition) • # Rossana de los Ríos (qualifying competition) • # Chan Yung-jan (qualifying competition) • # 🇫🇷 Émilie Loit (first round)

Qualifiers

• # 🇫🇷 Alizé Cornet • # 🇷🇺 Elena Vesnina • # 🇷🇴 Monica Niculescu • # 🇨🇿 Klára Zakopalová • # 🇨🇿 Iveta Benešová • # 🇪🇪 Kaia Kanepi • # 🇺🇦 Mariya Koryttseva • # 🇷🇺 Alisa Kleybanova • # 🇺🇿 Akgul Amanmuradova • # 🇺🇸 Jill Craybas • # 🇨🇳 Peng Shuai • # 🇧🇬 Tsvetana Pironkova

Lucky losers

• # 🇷🇺 Anastasia Rodionova • # 🇪🇸 Virginia Ruano Pascual • # 🇷🇺 Ekaterina Makarova • # 🇺🇦 Olga Savchuk

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

Seventh qualifier

Eighth qualifier

Ninth qualifier

Tenth qualifier

Eleventh qualifier

Twelfth qualifier