The 2006 US Open began August 28 and finished on September 10, 2006. Roger Federer was successful in defending his 2005 title, defeating 2003 champion Andy Roddick in the final. Kim Clijsters was unable to defend her title due to injury. 19-year-old Maria Sharapova won her second Grand Slam title, defeating Justine Henin-Hardenne in the final. It was Henin-Hardenne's third Grand Slam final loss of 2006, having lost the Australian Open and Wimbledon finals earlier in the year.

Seniors

Men's singles

Roger Federer defeated 🇺🇸 Andy Roddick, 6–2, 4–6, 7–5, 6–1

Women's singles

🇷🇺 Maria Sharapova defeated 🇧🇪 Justine Henin-Hardenne, 6–4, 6–4

Men's doubles

🇨🇿 Martin Damm / 🇮🇳 Leander Paes defeated 🇸🇪 Jonas Björkman / 🇧🇾 Max Mirnyi, 6–7(5–7), 6–4, 6–3

Women's doubles

🇫🇷 Nathalie Dechy / 🇷🇺 Vera Zvonareva defeated 🇷🇺 Dinara Safina / 🇸🇮 Katarina Srebotnik, 7–6(7–5), 7–5

Mixed doubles

🇺🇸 Martina Navratilova / 🇺🇸 Bob Bryan defeated 🇨🇿 Květa Peschke / 🇨🇿 Martin Damm, 6–2, 6–3

Juniors

Boys' singles

🇨🇿 Dušan Lojda defeated 🇨🇦 Peter Polansky 7-6(7–4), 6-3

Girls' singles

🇷🇺 Anastasia Pavlyuchenkova defeated 🇦🇹 Tamira Paszek 3–6, 6–4, 7–5

Boys' doubles

🇺🇸 Jamie Hunt / 🇺🇸 Nathaniel Schnugg defeated 🇺🇸 Jarmere Jenkins/🇺🇸 Austin Krajicek 6–3, 6-3

Girls' doubles

🇷🇴 Mihaela Buzărnescu / 🇷🇴 Ioana Raluca Olaru defeated 🇨🇦 Sharon Fichman/🇷🇺 Anastasia Pavlyuchenkova 7–5, 6-2

Wheelchair

Men's wheelchair singles

** Robin Ammerlaan** defeated 🇫🇷 Michaël Jérémiasz 6-7(1–7), 6–3, 7-5

Women's wheelchair singles

** Esther Vergeer** defeated Sharon Walraven 6–1, 6-2

Men's wheelchair doubles

** Robin Ammerlaan** / 🇫🇷 Michaël Jérémiasz defeated 🇯🇵 Shingo Kunieda / 🇵🇱 Tadeusz Kruszelnicki 7-6(7–2), 6-1

Women's wheelchair doubles

** Jiske Griffioen** / ** Esther Vergeer** defeated Korie Homan / Maaike Smit 6–4, 6-4

Seeds

Men's singles

Top 10 elimination

Withdrawn players

Player of the day