Roger Federer defeated James Blake in the final, 6–0, 6–3, 6–4 to win the singles tennis title at the 2006 Tennis Masters Cup. It was his third Tour Finals title. David Nalbandian was the defending champion, but was defeated in the semifinals by Blake.

Seeds

• # Roger Federer (champion) • # 🇪🇸 Rafael Nadal (semifinals) • # 🇷🇺 Nikolay Davydenko (round robin) • # Ivan Ljubičić (round robin) • # 🇺🇸 Andy Roddick (round robin) • # 🇪🇸 Tommy Robredo (round robin) • # 🇦🇷 David Nalbandian (semifinals) • # 🇺🇸 James Blake (final)

Alternates

• # Mario Ančić (Did not play) • # 🇨🇿 Tomáš Berdych (Did not play)

Draw

Finals

Red group

''Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.''

Gold group

''Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.''