Two-time defending champion Roger Federer defeated James Blake in the final, 7–5, 6–3, 6–0 to win the men's singles tennis title at the 2006 Indian Wells Masters.

Seeds

All seeds receive a bye into the second round. • # Roger Federer (champion) • # 🇪🇸 Rafael Nadal (semifinals) • # 🇺🇸 Andy Roddick (fourth round) • # 🇦🇷 David Nalbandian (fourth round) • # 🇷🇺 Nikolay Davydenko (third round) • # Ivan Ljubičić (quarterfinals) • # 🇦🇷 Gastón Gaudio (third round) • # 🇺🇸 Andre Agassi (third round) • # 🇦🇺 Lleyton Hewitt (third round) • # 🇪🇸 David Ferrer (second round) • # 🇩🇪 Nicolas Kiefer (second round) • # 🇺🇸 James Blake (final) • # Fernando González (second round) • # 🇪🇸 Juan Carlos Ferrero (third round) • # 🇨🇿 Radek Štěpánek (second round) • # 🇫🇷 Richard Gasquet (fourth round) • # 🇪🇸 Tommy Robredo (third round) • # 🇺🇸 Robby Ginepri (second round) • # 🇸🇰 Dominik Hrbatý (third round) • # 🇫🇷 Sébastien Grosjean (fourth round) • # Mario Ančić (fourth round) • # 🇫🇮 Jarkko Nieminen (quarterfinals) • # 🇨🇿 Tomáš Berdych (fourth round) • # 🇷🇺 Igor Andreev (quarterfinals) • # 🇨🇾 Marcos Baghdatis (quarterfinals) • # 🇩🇪 Tommy Haas (fourth round) • # 🇫🇷 Gaël Monfils (third round) • # 🇪🇸 Carlos Moyà (second round) • # 🇦🇷 Juan Ignacio Chela (second round) • # 🇧🇪 Olivier Rochus (third round) • # 🇮🇹 Filippo Volandri (second round) • # 🇪🇸 Fernando Verdasco (third round)

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8