The 2006 National Rugby League season consisted of 25 weekly regular season rounds starting on 11 March, followed by four weeks of play-offs that culminated in a grand final on 1 October.

Regular season

Round 1

Round 2

Round 3

Round 4

Round 5

Round 6

A very rare event occurred in Round 6 – a referee was injured during a match. In the 28th minute of the Newcastle vs Nth Qld match, referee Paul Simpkins blew time off and made his way off the field with an injured calf muscle. A replacement referee was organised – Tony De Las Heras, who had refereed the Jersey Flegg (third-tier competition) match earlier, was brought onto the field to take control of the rest of the match. Coincidentally, De Las Heras was the subject of the next instance a referee was injured in an NRL match, in Round 19, 2009. Also, for the first time in 8 years, first grade competitive rugby league returned to Adelaide after the Adelaide Rams were excluded from the competition after the 1998 season. The Penrith Panthers hosted the Melbourne Storm at Hindmarsh Stadium, which was won by Melbourne 40-18. However, Rugby league officials were hoping for an attendance of at least 10,000, and were disappointed with the attendance of only 7,017.

Round 7

Round 8

Brisbane Broncos recorded their biggest comeback in the club's history when they came from 18-0 down at halftime to win 30-28 against the Canberra Raiders at Suncorp Stadium.

Round 9

Round 10

Round 11

Round 12

Round 13

It took 70 minutes to score a point in the St. George Illawarra Dragons and Parramatta Eels game with Parramatta's five-eighth John Morris popped over a field goal to make it 1-0 to Parramatta. But eventually St. George Illwarra found their rhythm to go out 8-1 winners.

Round 14

Round 15

Round 16

Round 17

Round 18

Round 19

Round 20

Round 21

Round 22

Round 23

Round 24

Round 25

Round 26

Finals

Week One

First Qualifying Final

Second Qualifying Final

Third Qualifying Final

Fourth Qualifying Final

There was major controversy in this match when, approximately 15 minutes from full-time, Parramatta second-rower Glenn Morrison crashed over the Melbourne Storm line. With the decision sent to the Video Referee (Bill Harrigan) it appeared that Morrison deserved a Try- Benefit of the doubt. However, Harrigan ruled he had been held up by Storm fullback Billy Slater and the try was not awarded.

Week Two

First Semi Final

Second Semi Final

Week Three

First Preliminary Final

Second Preliminary Final

Grand final