The 2006 NASDAQ-100 Open was the 22nd edition of this tennis tournament and was played on outdoor hard courts. The tournament was part of the ATP Masters Series of the 2006 ATP Tour and was classified as a Tier I event on the 2006 WTA Tour. Both the men's and the women's events took place at the Tennis Center at Crandon Park in Key Biscayne, Florida, United States, from March 20 through April 2, 2006.

Finals

Men's singles

Roger Federer defeated Ivan Ljubičić 7–6(7–5), 7–6(7–4), 7–6(8–6)

Women's singles

🇷🇺 Svetlana Kuznetsova defeated 🇷🇺 Maria Sharapova 6–4, 6–3

Men's doubles

🇸🇪 Jonas Björkman & 🇧🇾 Max Mirnyi defeated 🇺🇸 Bob Bryan & 🇺🇸 Mike Bryan 6–4, 6–4

Women's doubles

🇺🇸 Lisa Raymond & 🇦🇺 Samantha Stosur defeated Liezel Huber & 🇺🇸 Martina Navratilova 6–4, 7–5