The 2006 Jacksonville Jaguars season was the franchise's 12th season in the National Football League (NFL) and the 4th under head coach Jack Del Rio. The Jaguars failed to improve on their 12–4 record from 2005. The Jaguars finished in third place in the AFC South and finished the season at 8–8. Although the Jaguars were 8–5 after thirteen games, they lost their next three games in a row and missed the postseason for the second time in three seasons.

Offseason

NFL draft

Staff

Final roster

Preseason

Regular season

Schedule

Note: Intra-division opponents are in bold text.

Game summaries

Week 1: vs. Dallas Cowboys

Week 2: vs. Pittsburgh Steelers

Week 3: at Indianapolis Colts

The Jaguars' defense effectively limited the Colts' offense to 66 yards and 3 first downs in the first half. However, the Jaguars could not capitalize on this strong defensive performance due to several errors. Leftwich threw an interception on their second possession while deep in Colts territory. Following that, they were forced to punt, and Colts' returner Terrence Wilkins ran back 82 yards, which resulted in the only points for the Colts in the first half. Additionally, on their final drive before halftime, Josh Scobee missed a 24–yard field goal attempt and later failed to convert a 49–yard field goal near the end of the third quarter. Ultimately, the Colts managed to score two touchdowns, securing a 21–14 victory. Manning achieved a completion rate of under 50 percent, connecting on 14 out of 31 attempts for a total of 219 yards.

Week 4: at Washington Redskins

Week 5: vs. New York Jets

Week 7: at Houston Texans

Week 8: at Philadelphia Eagles

Week 9: vs. Tennessee Titans

Week 10: vs. Houston Texans

Week 11: vs. New York Giants

Week 12: at Buffalo Bills

Week 13: at Miami Dolphins

Week 14: vs. Indianapolis Colts

On the first play from scrimmage for the Jaguars, Fred Taylor gained 76 yards on a run into Colts territory, followed by an 18–yard rushing touchdown by rookie running back Maurice Jones-Drew. After a Colts touchdown, Jones-Drew rushed twice for a total of 34 yards, followed by Taylor's 19–yard run and a 21–yard rushing touchdown. Following an interception thrown by Manning, Jones-Drew added a 48–yard rushing touchdown. The Jaguars capped off the first half with a field goal, leading 24–10 at halftime. On the second-half kickoff, Jones-Drew made a 93–yard return for a touchdown. He further contributed with an additional 48 rushing yards, while running back Alvin Pearman stepped in for Taylor, rushing for 73 yards, which included a 6–yard touchdown run. The running backs' collective rushing performance played a pivotal role in securing a decisive 44–17 victory against the Colts. During this game, the Jaguars combined for 375 rushing yards, the second-most in a single game since the AFL–NFL merger. Maurice Jones-Drew had a franchise-record 302 all-purpose yards; 166 rushing yards with two touchdowns, 15 receiving yards, and 121 return yards with a kickoff return touchdown. Fred Taylor had 131 rushing yards with one touchdown. Alvin Pearman contributed 71 rushing yards on 13 carries with one touchdown.

Week 15: at Tennessee Titans

Week 16: vs. New England Patriots

Week 17: at Kansas City Chiefs

Standings

Division

Conference