The 2005 CAF Champions League was the 41st edition of the CAF Champions League, the Africa's premier club football tournament prize organized by the Confederation of African Football (CAF). It was started on 29 January 2005 with a preliminary round. Al Ahly of Egypt defeated Étoile du Sahel of Tunisia in the final to win their fourth title.

Qualifying rounds

Preliminary round

1 Wallidan FC were withdrawn by the Gambia Football Federation.

First round

Second round

Group stage

Group A

Group B

Knockout stage

Bracket

Semi-finals

The first leg was played on 24–25 September and the second on 15–16 October.

Final

Top goalscorers

The top scorers from the 2005 CAF Champions League are as follows: