The UEFA Women's Cup 2005–06 was the fifth edition of the UEFA Women's Cup football club tournament. It was won by 1. FFC Frankfurt in an all-German final against defending champions FFC Turbine Potsdam for their second title in the competition.

First qualifying round

Group A1

Matches were played in Sintra, Portugal.

Group A2

Matches were played in Zagreb, Croatia.

Group A3

Matches were played in Zeist, the Netherlands.

Group A4

Matches were played in Jakobstad, Finland.

Group A5

Matches were played in Struga, Macedonia.

Group A6

Matches were played in Prague and Slaný, Czech Republic.

Group A7

Matches were played in Wroclaw, Poland.

Group A8

Matches were played in Sarajevo, Bosnia and Herzegovina.

Group A9

Matches were played in Sofia, Bulgaria.

Second qualifying round

Group B1

Matches were played in Montpellier, France.

Group B2

Matches were played in Stockholm, Sweden.

Group B3

Matches were played in Luzern, Switzerland.

Group B4

Matches were played in Copenhagen, Denmark.

Quarter-finals

First leg

Second leg

Semi-finals

First leg

Second leg

Final

First leg

Second leg

Top goalscorers

(excluding qualifying rounds)