The 2005–06 KNVB Cup was the 88th edition of the Dutch national football annual knockout tournament for the KNVB Cup. 87 teams contested, beginning on 2 August 2005 and ending at the final on 7 May 2006. Ajax beat PSV 2–1 in the final, winning the trophy for the sixteenth time.

Teams

Qualifying round

First round

E Eredivisie; 1 Eerste Divisie; A Amateur teams

Second round

Third round

Last 16

Six Eredivisie teams entered the tournament this round. They had previously been playing in the Champions League and UEFA Cup. E six Eredivisie entrants

Quarter finals

Semi-finals

Final

Both Ajax and PSV already secured a Champions League spot in the national competition. Therefore, the UEFA Cup ticket the winner of this tournament would win, could now be won in the Eredivisie play-offs.