The 2001 US Open was held between August 27 – September 9, 2001. It was the final Grand Slam event of 2001. Marat Safin was unsuccessful in his title defence, being defeated in the semifinals by Pete Sampras in a rematch of the 2000 final, while Venus Williams was successful in her title defense, beating her sister Serena in the women's final. 20-year-old Australian Lleyton Hewitt won the men's title, defeating Sampras in the final. It was the second consecutive US Open final defeat for Sampras.

Seniors

Men's singles

🇦🇺 Lleyton Hewitt defeated 🇺🇸 Pete Sampras, 7–6(7–4), 6–1, 6–1

Women's singles

🇺🇸 Venus Williams defeated 🇺🇸 Serena Williams, 6–2, 6–4

Men's doubles

Wayne Black / Kevin Ullyett defeated 🇺🇸 Donald Johnson / 🇺🇸 Jared Palmer, 7–6, 2–6, 6–3

Women's doubles

🇺🇸 Lisa Raymond / 🇦🇺 Rennae Stubbs defeated 🇺🇸 Kimberly Po / 🇫🇷 Nathalie Tauziat, 6–2, 5–7, 7–5

Mixed doubles

🇦🇺 Rennae Stubbs / 🇦🇺 Todd Woodbridge defeated 🇺🇸 Lisa Raymond / 🇮🇳 Leander Paes, 6–4, 5–7, [11–9]

Juniors

Boys' singles

🇱🇺 Gilles Müller defeated Yeu-Tzuoo Wang, 7–6(5), 6–2.

Girls' singles

🇫🇷 Marion Bartoli defeated 🇷🇺 Svetlana Kuznetsova, 4–6, 6–3, 6–4.

Boys' doubles

🇨🇿 Tomáš Berdych / Stéphane Bohli defeated 🇺🇸 Brendan Evans / 🇺🇸 Brett Joelson, 6–4, 6–4.

Girls' doubles

🇷🇺 Galina Fokina / 🇷🇺 Svetlana Kuznetsova defeated Jelena Janković / Matea Mezak, 7–5, 6–3.