Andre Agassi defeated the defending champion Yevgeny Kafelnikov in the final, 3–6, 6–3, 6–2, 6–4 to win the men's singles tennis title at the 2000 Australian Open. It was his second Australian Open title and sixth major title overall. It was also Agassi's fourth consecutive major final, making him the first man to reach all four major finals consecutively since Rod Laver in 1969. With the win, Agassi became the reigning champion at three of the four majors, missing only the 1999 Wimbledon Championships (where he had finished runner-up to Pete Sampras). This was the first Australian Open for future six-time champion and world No. 1 Roger Federer, and marked his first match win at a major. Also, this marked the beginning of Federer's 65-consecutive major appearance streak and his 21-consecutive Australian Open appearance streak. This tournament marked the final major appearance of former world No. 1 and two-time champion Jim Courier.

Seeds

• # 🇺🇸 Andre Agassi (champion) • # 🇷🇺 Yevgeny Kafelnikov (final) • # 🇺🇸 Pete Sampras (semifinals) • # 🇩🇪 Nicolas Kiefer (quarterfinals) • # 🇧🇷 Gustavo Kuerten (first round) • # 🇸🇪 Thomas Enqvist (first round) • # 🇪🇨 Nicolás Lapentti (second round) • # 🇺🇸 Todd Martin (second round) • # 🇳🇱 Richard Krajicek (second round) • # 🇩🇪 Tommy Haas (second round) • # 🇬🇧 Tim Henman (fourth round) • # 🇸🇪 Magnus Norman (semifinals) • # 🇫🇷 Cédric Pioline (first round) • # 🇸🇰 Karol Kučera (first round) • # 🇪🇸 Albert Costa (first round) • # 🇦🇺 Mark Philippoussis (fourth round)

Qualifying

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8

Singles overview

Men's singles