The 2000 season was the Arizona Cardinals' 81st season in the National Football League (NFL), their 102nd overall and their 13th in Arizona. The Cardinals ranked 24th in the NFL in total offense and 30th in total defense. The Cardinals ranked last in the NFC in Takeaways/Giveaways with a rating of −24. The Cardinals surrendered 443 points in 2000, the second-worst in the NFL that season, and second-worst in franchise history. Arizona's minus-233 point differential is the worst in team history. Two of the Cardinals' three victories came by one point each, and they were 0–8 on the road. Following the most lopsided of those eight road losses, 48–7 at Dallas in week eight, coach Vince Tobin was fired, ending his tenure in the desert after 4½ seasons with a 29–44 record. Defensive coordinator Dave McGinnis was named interim coach, and he held the job through the end of the 2003 season. The 3–13 mark would be matched in 2018. The Cardinals suffered through their poorest season since the 1970 AFL–NFL merger, eclipsing the 4–12 marks of 1991, 1992, 1995 and 1997. The Cardinals also went 4–9–1 in 1971, 1972 and 1973, and 4–11–1 in 1986, and would suffer through another 4–12 campaign in 2003.

Offseason

Signings

Re-signings

Departures

NFL draft

Undrafted free agents

Personnel

Staff

Roster

Preseason

Regular season

On December 18, Dave McGinnis was named as the 38th head coach in franchise history. He had been interim coach since October 23, when Vince Tobin was fired.

Schedule

Note: Intra-division opponents are in bold text.

Game summaries

Week 1: at New York Giants

Week 2: vs. Dallas Cowboys

Week 4: vs. Green Bay Packers

Week 5: at San Francisco 49ers

Week 6: vs. Cleveland Browns

Week 7: vs. Philadelphia Eagles

Week 8: at Dallas Cowboys

Week 9: vs. New Orleans Saints

Week 10: vs. Washington Redskins

Week 11: at Minnesota Vikings

Week 12: at Philadelphia Eagles

Week 13: vs. New York Giants

Week 14: at Cincinnati Bengals

Week 15: at Jacksonville Jaguars

Week 16: vs. Baltimore Ravens

Week 17: at Washington Redskins

Standings

Best performances

Records