The 2000–01 St. Louis Blues season was the 34th for the franchise in St. Louis, Missouri. After winning the Presidents' Trophy the previous season, the Blues finished the regular-season with a record of 43 wins, 22 losses, 12 ties and 5 overtime losses, enough for 103 points and a trip to the 2001 Stanley Cup playoffs. In the Western Conference Quarterfinals, the Blues defeated the San Jose Sharks in six games, then swept the Pacific Division-winning Dallas Stars in the Conference Semifinals before losing in five games to the eventual Stanley Cup champion Colorado Avalanche in the Conference Finals.

Off-season

Regular season

Final standings

Playoffs

Schedule and results

Regular season

Playoffs

Player statistics

Scoring

Goaltending

Awards and records

Awards

Milestones

Transactions

The Blues were involved in the following transactions from June 11, 2000, the day after the deciding game of the 2000 Stanley Cup Finals, through June 9, 2001, the day of the deciding game of the 2001 Stanley Cup Finals.

Trades

Players acquired

Players lost

Signings

Draft picks

St. Louis's draft picks at the 2000 NHL entry draft held at the Pengrowth Saddledome in Calgary, Alberta.