Serena Williams defeated Steffi Graf in the final, 6–3, 3–6, 7–5 to win the women's singles tennis title at the 1999 Indian Wells Open. It was the second and last time that the two would contest a professional match. Martina Hingis was the defending champion, but lost in the quarterfinals to Chanda Rubin.

Seeds

The top eight seeds received a bye to the second round. • # Martina Hingis (quarterfinals) • # 🇺🇸 Lindsay Davenport (second round) • # 🇺🇸 Monica Seles (third round) • # 🇨🇿 Jana Novotná (quarterfinals) • # 🇩🇪 Steffi Graf (final) • # 🇫🇷 Mary Pierce (quarterfinals) • # Amanda Coetzer (third round) • # 🇫🇷 Nathalie Tauziat (third round) • # 🇷🇺 Anna Kournikova (first round) • # Patty Schnyder (third round) • # 🇧🇪 Dominique Van Roost (first round) • # 🇫🇷 Sandrine Testud (semifinals) • # Irina Spîrlea (second round) • # 🇪🇸 Conchita Martínez (second round) • # 🇧🇾 Natasha Zvereva (first round) • # 🇦🇹 Barbara Schett (first round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

Qualifying

Seeds

• # 🇪🇸 María Sánchez Lorenzo (Qualifier) • # 🇫🇷 Alexia Dechaume-Balleret (qualifying competition) • # 🇩🇪 Barbara Rittner (Qualifier) • # 🇺🇸 Kimberly Po (first round) • # Kristina Brandi (qualifying competition) • # 🇷🇴 Cătălina Cristea (qualifying competition) • # 🇩🇪 Andrea Glass (Qualifier) • # 🇺🇸 Meghann Shaughnessy (qualifying competition)

Qualifiers

• # 🇪🇸 María Sánchez Lorenzo • # 🇦🇺 Alicia Molik • # 🇺🇸 Brie Rippner • # Jessica Steck • # 🇩🇪 Andrea Glass • # 🇩🇪 Barbara Rittner • # 🇯🇵 Miho Saeki • # 🇷🇺 Tatiana Panova

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

Seventh qualifier

Eighth qualifier