The 1999–2000 League of Ireland Premier Division was the 15th season of the League of Ireland Premier Division. The division was made up of 12 teams. Shelbourne won the title.

Regular season

The season saw each team playing three rounds of games, playing every other team three times, totalling 33 games.

Final Table

Results

Matches 1–22

Matches 23–33

Promotion/relegation play-off

Waterford United who finished in tenth place played off against Kilkenny City, the third placed team from the 1999–2000 League of Ireland First Division.

1st leg

2nd leg

Kilkenny City won 2–0 on aggregate and were promoted to the Premier Division.