Defending champion Monica Seles defeated Arantxa Sánchez Vicario in the final, 6–3, 6–3 to win the women's singles tennis title at the 1992 US Open. She did not lose a set during the tournament. By reaching the final, Seles became the sixth woman, after Maureen Connolly, Margaret Court, Chris Evert, Martina Navratilova, and Steffi Graf to reach all four major finals in a calendar year.

Seeds

• # Monica Seles (champion) • # 🇩🇪 Steffi Graf (quarterfinals) • # 🇺🇸 Martina Navratilova (second round) • # 🇦🇷 Gabriela Sabatini (quarterfinals) • # 🇪🇸 Arantxa Sánchez Vicario (final) • # 🇺🇸 Jennifer Capriati (third round) • # 🇺🇸 Mary Joe Fernández (semifinals) • # 🇪🇸 Conchita Martínez (first round) • # Manuela Maleeva-Fragnière (semifinals) • # Jana Novotná (first round) • # 🇩🇪 Anke Huber (first round) • # 🇫🇷 Nathalie Tauziat (second round) • # Helena Suková (fourth round) • # 🇺🇸 Zina Garrison (fourth round) • # 🇧🇬 Katerina Maleeva (third round) • # 🇫🇷 Mary Pierce (fourth round)

Qualifying

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8