The 1981 CONCACAF Champions' Cup was the 17th edition of the annual international club football competition held in the CONCACAF region (North America, Central America and the Caribbean), the CONCACAF Champions' Cup. It determined that year's club champion of association football in the CONCACAF region and was played from 26 April 1980 to 2 February 1981. The teams were split in two zones, North/Central American and Caribbean, each one qualifying the winner to the final tournament. All the matches in the tournament were played under the home/away match system. Surinamean team Transvaal won the two-legged series against Salvadorean Atlético Marte (2–1 on aggregate), becoming CONCACAF champions for the second time in their history.

North/Central American Zone

First round

Second round

Third round

Caribbean Zone

First round

result 2nd leg not known, Transvaal qualified. other fixtures not known but apparently Yama Sun Oil eliminated Saint Thomas College (home country unclear)

Second round

Third round

Final

x both matches in Paramaribo

First leg

Second leg

Transvaal won 2–1 on aggregate.

Champion