The Copa Libertadores 1980 was the 21st edition of the Copa Libertadores, CONMEBOL's annual international club tournament. Nacional of Uruguay won the competition defeating Brazilian club Internacional. Defending champion Olimpia were eliminated in the semifinals.

Qualified teams

Draw

The champions and runners-up of each football association were drawn into the same group along with another football association's participating teams. Three clubs from Paraguay competed as Olimpia was champion of the 1979 Copa Libertadores. They entered the tournament in the Semifinals.

Group stage

Group 1

Play Off Vélez Sársfield 1-1 a.e.t. River Plate Vélez Sarsfield qualify on better goal difference in group

Group 2

Group 3

Group 4

Group 5

Semifinals

Group A

Group B

Finals

Champion