The 1980–81 Pittsburgh Penguins season was their 14th in the National Hockey League.

Regular season

Division standings

Record vs. opponents

Schedule and results

Playoffs

The Penguins lost in the Preliminary round (3–2) versus the St. Louis Blues.

Player statistics

†Denotes player spent time with another team before joining the Penguins. Stats reflect time with the Penguins only. ‡Denotes player was traded mid-season. Stats reflect time with the Penguins only.

Awards and records

Transactions

The Penguins were involved in the following transactions during the 1980–81 season:

Trades

Additions and subtractions

Draft picks

The 1980 NHL Entry Draft was held on June 11, 1980, in Montreal.