The 1965 Chicago White Sox season was the team's 65th season in the major leagues, and its 66th season overall. They finished with a record of 95–67, good enough for second place in the American League, 7 games behind the first-place Minnesota Twins. This would be Al Lopez's final full season as White Sox manager.

Offseason

Regular season

Season standings

Record vs. opponents

Opening Day lineup

Notable transactions

Roster

Player stats

Batting

Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; BB = Base on balls; SO = Strikeouts; AVG = Batting average; SB = Stolen bases

Pitching

Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; HR = Home runs allowed; BB = Walks allowed; K = Strikeouts

Farm system

LEAGUE CHAMPIONS: Tidewater