The 1964–65 African Cup of Champions Clubs, known as Kwame Nkrumah Cup was the first edition of the annual international club football competition held in the CAF region (Africa), the African Cup of Champions Clubs. It determined that year's club champion of association football in Africa. The tournament was played by 14 teams. They were split in 3 groups, with each group winner qualifying to the final tournament held in Ghana. Oryx Douala from Cameroon won the final, and became the first CAF club champion.

Preliminary round

Fourteen teams entered the preliminary round, divided over three zones. Real Republicans of Ghana qualified as the host of the final tournament.

North-Eastern Zone

First round

Second round

Cotton Factory Club qualified.

Western Zone

First round

Stade Malien won 5–1 on aggregate. Sily CK won 6–4 on aggregate. ASEC Mimosas won after Étoile Filante withdrew. AS Porto-Novo won after Port Harcourt FC withdrew.

Second round

As the aggregate finished 4–4, a replay was required. Stade Malien qualified. ASEC Mimosas won 5–3 on aggregate.

Third round

Stade Malien won 9–7 on aggregate and qualified.

Central-South-Western Zone

Oryx Douala won 5–4 on aggregate and qualified.

Final tournament

The final tournament was held in Accra and Kumasi, Ghana.

Semi-finals

Bronze-medal match

Final

Champion

Top scorers

The top scorers from the 1964–65 African Cup of Champions Clubs are as follows: