The 1961 St. Louis Cardinals season was the team's 80th season in St. Louis, Missouri and its 70th season in the National League. The Cardinals went 80–74 during the season and finished fifth in the National League. It was the last season before the NL went to a 162-game schedule the following season to adjust for the new ten-team league.

Offseason

Regular season

On July 6, with the Cardinals at 33–41, manager Solly Hemus was fired and replaced by Johnny Keane. The team went 47–33 under Keane. First baseman Bill White and third baseman Ken Boyer won Gold Gloves this year.

Season standings

Record vs. opponents

Notable transactions

Roster

Player stats

Batting

Starters by position

''Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Other batters

''Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Pitching

Starting pitchers

Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Other pitchers

Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Relief pitchers

Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts

Farm system

San Juan franchise moved to Charleston (WV), May 19, 1961