The 1942 NFL draft was held on December 22, 1941, at the Palmer House Hotel in Chicago. Two members of the draft class have been inducted into the Pro Football Hall of Fame, Bill Dudley, the first overall selection by the Pittsburgh Steelers, and Mac Speedie, 135th overall selection by the Detroit Lions. Additionally, one member of the draft class became a Naismith Memorial Basketball Hall of Fame college basketball coach, Ralph Miller. Miller was selected 167th pick overall by the Brooklyn Dodgers after successful careers at Kansas on the school's football and basketball teams.

Player selections

Round one

Round two

Round three

Round four

Round five

Round six

Round seven

Round eight

Round nine

Round ten

Round eleven

Round twelve

Round thirteen

Round fourteen

Round fifteen

Round sixteen

Round seventeen

Round eighteen

Round nineteen

Round twenty

Round twenty-one

Round twenty-two

Hall of Famers

Notable undrafted players