The Netherlands Football League Championship 1921–1922 was contested by 43 teams participating in four divisions. The national champion would be determined by a play-off featuring the winners of the eastern, northern, southern and western football division of the Netherlands. Go Ahead won this year's championship by beating Blauw-Wit Amsterdam, NAC, and Be Quick 1887.

New entrants

Eerste Klasse East: Eerste Klasse North: Eerste Klasse South: Eerste Klasse West:

Divisions

Eerste Klasse East

Eerste Klasse North

Eerste Klasse South

Eerste Klasse West

Championship play-off

Play-off

Go Ahead won the championship.