The 1920-21 season was the first divided into two leagues, the Liga Mexicana and Liga Nacional were played. After the expulsion of Tigres México from the league, España FC and España Veracruz withdrew in solidarity. España FC changed its name to "Real España" and decided to form their own league called Liga Nacional. Due to the separation of the leagues, both tournaments and champions were not recognized by the organizing body, which was the Asociación de Aficionados de México en la Liga de Football.

Standings

Liga Mexicana

The 5 participating teams from Mexico City, and all the matches were played at Parque Asturias. Pachuca AC and Deportivo Español were dissolved. In replacement Deportivo Internacional and Club Morelos joined the league.

Liga Nacional

The 5 participating teams from Mexico City, and all the matches were played at Parque España. Reforma, América, Luz y Fuerza and L'Amicale Française joined the Liga Nacional.