The 1881 Buffalo Bisons finished the season with a 45–38 record, good for third place in the National League. A highlight from this season occurred on September 15. In a 12-inning game against Worcester, Buffalo second baseman Davy Force recorded 12 putouts, seven assists, two unassisted double plays, participated in a triple play, and made just one error in 20 chances.

Regular season

Season standings

Record vs. opponents

Roster

Player stats

Batting

Starters by position

''Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Other batters

''Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Pitching

Starting pitchers

Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Other pitchers

Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts