Before the widespread adoption of ASCII in the late 1960s, six-bit character codes were common and a 12-bit word, which could hold two characters, was a convenient size. This also made it useful for storing a single decimal digit along with a sign. Possibly the best-known 12-bit CPU is the PDP-8 and its relatives, such as the Intersil 6100 microprocessor produced in various forms from August 1963 to mid-1990. Many analog to digital converters (ADCs) have a 12-bit resolution. Some PIC microcontrollers use a 12-bit word size. 12 binary digits, or 3 nibbles (a 'tribble'), have 4096 (10000 octal, 1000 hexadecimal) distinct combinations. Hence, a microprocessor with 12-bit memory addresses can directly access 4096 words (4 kW) of word-addressable memory. IBM System/360 instruction formats use a 12-bit displacement field which, added to the contents of a base register, can address 4096 bytes of memory in a region that begins at the address in the base register.

List of 12-bit computer systems